Name: CHIR-99021
SKU: 252917-06-9
Availability: InStock

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HANGZHOU TIANYE CHEMICALS CO., LTD.

Country: China (Mainland)

Business Type:Trading Company

: Ms.Miranda Liu

Tel: 0571-85083592
: Mr.Gao

Tel: 0571-85085803
: Ms.anna xiong

Tel: 0571-87065260

Mobile: 18658191951

Tel: 0571-85083592

Fax: 0571-85085803

URL: http://www.tianyechem.cn

Province/state: Zhejiang

City: Hangzhou

Street: 1208# HuaCe Building-B,Wuchanggang Road,XIHU District,Hangzhou City,Zhejiang Province ,China

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CHIR-99021

CAS NO.252917-06-9

Min.Order: 1 Gram
Payment Terms: L/C,D/A,D/P,T/T,Other
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CHIR-99021
252917-06-9
0.99

Quick Details

ProName: CHIR-99021
CasNo: 252917-06-9
Molecular Formula: C22H18Cl2N8
Appearance: white to light brown powder
Application: intermediate
DeliveryTime: Keep hundreds kgs stock
PackAge: drum
Port: SHANGHAI
ProductionCapacity: 1 Kilogram/Month
Purity: 0.97
Storage: -20°C
Transportation: According to your request
LimitNum: 1 Gram

Superiority

Product Name:	CHIR-99021
Synonyms:	6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile;6-{2-[4-(2,4-Dichloro-phenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino]-ethylamino}-nicotinonitrile;CHIR-99021;CT99021;GSK-3 Inhibitor XVI;3-Pyridinecarbonitrile, 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino];CT99021;CHIR99021;CHIR 99021;CT-99021;CT 99021(CHIR 99021)
CAS:	252917-06-9
MF:	C22H18Cl2N8
MW:	465.34
EINECS:	809-015-4
Product Categories:	Inhibitors;Antineoplastic;Anti-cancer&immunity;PI3K/Akt/mTOR;Akt;mTOR;PI3K
Mol File:	252917-06-9.mol

Uses	Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that plays a key inhibitory role in both the insulin and Wnt signaling pathways. CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively. When tested against twenty different protein kinases, this inhibitor shows greater than 500-fold selectivity for GSK3. CHIR99021 activates glycogen synthesis in CHO-IR cells (EC50 = 0.8 μM) and in isolated type 1 diabetic rat skeletal muscle. A single oral dose (30 mg/kg) of CHIR99021 enhances in vivo glucose metabolism in a rodent model of type 2 diabetes. CHIR99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells.
Uses	A specific GSK-3 inhibitor of GSK-3β and GSK-3α with IC50s of 5 nM and 10 nM, respectively.
Uses	CHIR99021 has been used: in cocktail with small molecules to convert human lung fibroblast cells into neurons as a culture medium supplement in potassium supplemented simplex optimization medium (KSOM) for the culture of blastocysts for chronic inhibition of GSK-3 to investigate its role in corticogenesis

Details

HANGZHOU TIANYE CHEMICALS Co.LTD , Located in Eastern Science and Innovation Park Hangzhou .
We are a high-tech enterprise specialized in technical research and development, production, development and trade of chemical products.
We supply Multiple solutions for our customers include offering, research ,Contract Manufacturing Organization(CMO),Contract development and manufacturing organization(CDMO) .
We have obtained ISO 9001 and ISO 14001 certificates to make sure supply more superior quality and Environmentally friendly chemicals .
Since 2009, we have provided various chemical products to customers around the world, And We practice the concept of "customer first" and hope to provide customers with all-round and high-quality services and will keep it all the time .
We are willing to become your trustworthy partner with high-quality products and sincere service!

We can provide customers with small quantities with gram level for laboratories research to tonnage level for industrial production Synthesis capacity from 1 liter to 5000 liter is available.