HANGZHOU TIANYE CHEMICALS CO., LTD.
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Business Type:Trading Company
Tel: 0571-85083592
Tel: 0571-85085803
Tel: 0571-87065260
Mobile: 18658191951
Tel: 0571-85083592
Fax: 0571-85085803
Province/state: Zhejiang
City: Hangzhou
Street: 1208# HuaCe Building-B,Wuchanggang Road,XIHU District,Hangzhou City,Zhejiang Province ,China
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CAS NO.143621-35-6
| Product Name: | 3-AP |
| Synonyms: | 3-Apct;C078157;Pan 811;Pan811;Pan-811;Triapine;2-((3-AMinopyridin-2-yl)Methylene)hydrazinecarbothioaMide;NSC 663249 |
| CAS: | 143621-35-6 |
| MF: | C7H9N5S |
| MW: | 195.24 |
| EINECS: | |
| Product Categories: | Inhibitors;API |
| Mol File: | 143621-35-6.mol |
| Uses | Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. At 5 μM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair. It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species. Furthermore, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis.[Cayman Chemical] |
HANGZHOU TIANYE CHEMICALS Co.LTD , Located in Eastern Science and Innovation Park Hangzhou .
We are a high-tech enterprise specialized in technical research and development, production, development and trade of chemical products.
We supply Multiple solutions for our customers include offering, research ,Contract Manufacturing Organization(CMO),Contract development and manufacturing organization(CDMO) .
We have obtained ISO 9001 and ISO 14001 certificates to make sure supply more superior quality and Environmentally friendly chemicals .
Since 2009, we have provided various chemical products to customers around the world, And We practice the concept of "customer first" and hope to provide customers with all-round and high-quality services and will keep it all the time .
We are willing to become your trustworthy partner with high-quality products and sincere service!
We can provide customers with small quantities with gram level for laboratories research to tonnage level for industrial production Synthesis capacity from 1 liter to 5000 liter is available.